Target List
Senescence Pathway
ATMBMI1CCND1CCNE1CDK2CDK4CDK6CDKN1A (p21CIP1, WAF1)CDKN2A (P16INK4A)CDKN2D (p19-INK4D)CHEK1CHEK2 (RAD53)E2F1E2F3ETS1ETS2MDM2RB1RBL2TP53 (p53)TWIST1
Senescence Initiators
p53 Signaling
ABL1
p53 / pRb Signaling & the Cell Cycle
AKT1ALDH1A3 (RALDH3)CCNA2CCNB1CDC25CCDKN1C (p57Kip2)CDKN2B (p15INK4b)CDKN2C (p18-INK4C)CITED2CREG1GSK3BID1IGF1RIGFBP3ING1MAP2K6 (MEK6, MKK6)MAPK14 (p38ALPHA)MORC3MYCPCNAPIK3CA (p110-alpha)PLAU (UPA)RBL1SERPINB2 (PAI-2)SERPINE1 (PAI-1)SIRT1SPARCTGFB1
Interferon Signaling
ALDH1A3 (RALDH3)CDKN1A (p21CIP1, WAF1)CDKN1B (P27KIP1)EGR1IFNGIGFBP3IGFBP7IRF3IRF5IRF7NFKB1RB1SERPINB2 (PAI-2)
Insulin Growth Factor (IGF) Related
IGF1IGF1RIGFBP3IGFBP5IGFBP7
MAP Kinase Signaling
HRASMAP2K1MAP2K3 (MEK3)MAP2K6 (MEK6, MKK6)MAPK14 (p38ALPHA)
Oxidative Stress
ALDH1A3 (RALDH3)HRASMAPK14 (p38ALPHA)NOX4PRKCDSOD1SOD2
DNA Damage & Repair
ATMGADD45ANBNPCNATERF2TERTTP53BP1
Senescence Responses
p53 Effectors
ALDH1A3 (RALDH3)E2F1HRASIGFBP3MYC
p21 Effectors
CALR
p16 Effectors
TBX2TBX3
Cytoskeleton Regulators
AKT1FN1HRASPIK3CA (p110-alpha)PLAU (UPA)SERPINE1 (PAI-1)SPARCTHBS1 (TSP-1)VIM
Cell Adhesion Molecules
CD44COL1A1COL3A1TGFB1TGFB1I1THBS1 (TSP-1)
Other Senescence Response Genes
GLB1PTEN