Target List
Unfolded Protein Binding
CALRCANXCCT4CCT7DNAJB2DNAJB9DNAJC10DNAJC4ERO1B (ERO1LB)HSPA1BHSPA2HTRA2PFDN2PFDN5PPIASCAPSEC63SIL1TCP1TOR1AUGGT1
Endoplasmic Reticulum Protein Folding Quality Control
EDEM1EDEM3ERP44GANABGANCPRKCSHRPN1SERP1UGGT1UGGT2
Regulation of Cholesterol Metabolism
INSIG1INSIG2MBTPS1MBTPS2SCAPSREBF1SREBF2
Regulation of Translation
EIF2AEIF2AK3PPP1R15A (GADD34)SERP1
Endoplasmic Reticulum Associated Degradation (ERAD)
AMFRDERL1DERL2EDEM1FBXO6HERPUD1HTRA2HTRA4MBTPS1MBTPS2NPLOC4NUCB1OS9SEC62SEL1LSELENOSSYVN1UBXN4VCP
Ubiquitination
AMFREDEM3HERPUD1RNF139RNF5SEC62SEL1LUBE2G2UBE2J2UBXN4UFD1USP14VCP
Transcription Factors
ATF4ATF6ATF6BATXN3CALRCEBPBCREB3CREB3L3DDIT3 (GADD153, CHOP)ERN1ERN2MBTPS1PFDN5SCAPSREBF1SREBF2XBP1
Protein Folding
CALRCANXCCT4CCT7DNAJB2DNAJB9DNAJC10DNAJC4ERO1A (ERO1L)ERP44HSPA4L (OSP94)PFDN2PFDN5PPIASEC63SIL1TCP1TOR1AUGGT1
Protein Disulfide Isomerization
DDIT3 (GADD153, CHOP)DNAJC10ERO1A (ERO1L)ERO1B (ERO1LB)ERP44PDIA3SELENOSSREBF1
Heat Shock Proteins
DNAJB2DNAJB9DNAJC10DNAJC3DNAJC4HSPA1LHSPA4 (HSP70)HSPA5 (GRP78)HSPH1 (HSP105)SEC63
Apoptosis
ATXN3BAXCALRCEBPBDDIT3 (GADD153, CHOP)EIF2AK3ERN1ERN2HSPA1BHTRA2MANFMAPK10 (JNK3)MAPK8 (JNK1)MAPK9 (JNK2)PDIA3PPP1R15A (GADD34)SELENOSVCP