Target List
Inflammasomes
AIM2
AIM2CASP1 (ICE)PYCARD (TMS1, ASC)
IPAF
CASP1 (ICE)NAIPNLRC4 (IPAF)PYCARD (TMS1, ASC)
NLRP1
CASP1 (ICE)CASP5NLRP1
NLRP3
CASP1 (ICE)NLRP3PYCARD (TMS1, ASC)
Negative Regulation of Inflammasomes
BCL2BCL2L1 (BCLXL)BCL2L1 (BCLXL)BCL2L1 (BCLXL)CARD18CD40LGCTSBHSP90AA1HSP90AB1HSP90B1MEFVPSTPIP1PYDC1 (POP1)SUGT1TNFTNFSF11 (RANKL)TNFSF14TNFSF4 (OX40L)
Signaling Downstream of Inflammasomes
IFNGIL12AIL12BIL18IL1BIL33IRAK1IRF1MYD88P2RX7PANX1PTGS2 (COX2)MOKRIPK2TIRAPTXNIP
NOD-Like Receptors
NOD-Like Receptors
CIITANAIPNLRC4 (IPAF)NLRC5NLRP1NLRP12NLRP3NLRP4NLRP5NLRP6NLRP9NLRX1NOD1 (CARD4)NOD2
Signaling Downstream of NOD-Like Receptors
BIRC2 (c-IAP1)BIRC3 (c-IAP2)CARD6CASP8 (FLICE)CCL2 (MCP-1)CCL5 (RANTES)CCL7 (MCP-3)CFLAR (CASPER)CHUK (IKKα)CXCL1 (GRO1, GROa, SCYB1)CXCL2 (GRO2, GROb, SCYB2)FADDIFNB1IKBKB (IKKβ)IKBKGIL6IRF1IRF2MAP3K7 (TAK1)MAPK1 (ERK2)MAPK11 (p38Beta)MAPK12 (p38GAMMA)MAPK13 (p38delta)MAPK3 (ERK1)MAPK8 (JNK1)MAPK9 (JNK2)NFKB1NFKBIA (IκBα, MAD3)NFKBIB (TRIP9)PEA15RELARIPK2SUGT1TAB1TAB2TNFTRAF6XIAP
Pro-Inflammatory Caspases
CASP1 (ICE)CASP5