Target List
Differentially Methylated Promoters
APBA1 (MINT1)APCCADM1 (TSLC1)CDH1 (E-Cadherin)CDH13CDKN1C (p57Kip2)CDKN2A (P16INK4A)CDKN2B (p15INK4b)CXCL12 (SDF1)CYP1B1DLC1FHITMGMT (AGT)MLH1MTHFROPCML (OBCAM)PRDM2 (RIZ1)RASSF1RASSF2SFRP1TCF21
Metastatic Potential
ANXA5DUSP6ERBB3HGFHMMRIRF4LCKMETMMDNF1STAT1STAT2
Differentially Expressed Genes in Adenocarcinoma (AC) Versus Squamous Cell Carcinoma (SCC)
Higher in Adenocarcinoma than in Squamous Cell Carcinoma
CLCA2DSG3KRT5KRT14SPRR1A
Higher in Squamous Cell Carcinoma than in Adenocarcinoma
AGR2LGSNNKX2-1SFTA3SPINK1
Up-Regulated in Lung Cancer
CEACAM5COL11A1CPCXCL13GREM1MKI67MMP1MMP12SPINK1SPP1TOP2ATOX3
Down-Regulated in Lung Cancer
AGERCA4CLDN18CLIC5FABP4GPM6ASCGB1A1SFTPCSOSTDC1WIF1
AKT & PI3 Kinase Signaling
AKT1BCL2CDH1 (E-Cadherin)CDKN2A (P16INK4A)EGFR (ERBB1)NFKB1TP53 (p53)VEGFA
Apoptosis
ANXA5APCBCL2BIRC5BRAFCADM1 (TSLC1)CDH1 (E-Cadherin)CDH13CDKN2A (P16INK4A)DLC1EGFR (ERBB1)ERBB2 (HER-2, NEU)ERBB3HGFHRASKRASLCKMLH1MMP9NF1NFKB1PTGS2 (COX2)SFRP1STAT1TERTTGFB1TNFTOP2ATP53 (p53)VEGFA
Regulation of the Cell Cycle
APCBCL2BIRC5CDKN1C (p57Kip2)CDKN2A (P16INK4A)CDKN2B (p15INK4b)EGFR (ERBB1)PTGS2 (COX2)RB1TGFB1TNFTP53 (p53)
Immune Response
BCL2CADM1 (TSLC1)CSF3 (GCSF)CXCL12 (SDF1)CXCL13IRF4LCKMLH1MMDNFKB1PAX5STAT1STAT2TGFB1TNFTP53 (p53)VEGFA
Extracellular Matrix (ECM) & Cell Adhesion Molecules
CADM1 (TSLC1)CDH1 (E-Cadherin)CDH13CEACAM6CLDN18COL11A1DSG3GPM6AHMMRKRT14KRT5METMMP1MMP12MMP9SFTA3SFTPC