Target List
Differentially Methylated Promoters
APCARCAV1CCNA1CDH1 (E-Cadherin)CDKN2A (P16INK4A)DKK3DLC1EDNRBGPX3GSTP1MGMT (AGT)MSX1PDLIM4 (RIL)PTGS2 (COX2)RARBRASSF1SFRP1SLC5A8TIMP2TNFRSF10DZNF185
Up-Regulated in Prostate Cancer
ARNTL (BMAL1)CAMSAP1DDX11ECT2ETV1HALIGFBP5KLK3MTO1PDPK1RBM39SOCS3SOX4SUPT7L
Down-Regulated in Prostate Cancer
CCND2CLN3GCAIGF1LGALS4LOXL1PPP2R1BSFRP1SLC5A8TFPI2USP5
Metastatic Potential
CREB1KLHL13MAXNDRG3PES1SEPT7SCAF11
Androgen Receptor Signaling
ARCAV1CCND1DAXXEGFR (ERBB1)FOXO1GNRH1IGF1IL6NFKB1NRIP1PTENSHBGTGFB1I1TIMP2TIMP3VEGFA
AKT & PI3 Kinase Signaling
AKT1ARBCL2CCND1CCND2CDH1 (E-Cadherin)CDKN2A (P16INK4A)EGFR (ERBB1)FOXO1GNRH1IGF1IL6MAPK1 (ERK2)NFKB1PDPK1PTENTIMP2TIMP3TNFRSF10DTP53 (p53)VEGFA
PTEN Signaling
AKT1EGFR (ERBB1)GNRH1IGF1IL6MAPK1 (ERK2)PDPK1PTENTIMP2TIMP3TP53 (p53)VEGFA
Apoptosis
BCL2CASP3CDKN2A (P16INK4A)EGFR (ERBB1)ETV1GNRH1IGF1IL6MAPK1 (ERK2)NFKB1PTENTIMP2TIMP3TP53 (p53)VEGFA
Cell Cycle
APCBCL2CASP3CAV2CCNA1CCND1CCND2CDKN2A (P16INK4A)EGFR (ERBB1)IGF1PPP2R1BPTENPTGS1 (COX1)PTGS2 (COX2)TP53 (p53)
Transcription Factors
ARARNTL (BMAL1)CDKN2A (P16INK4A)CREB1DAXXEGR3ERGETV1FOXO1MAXMSX1NFKB1NKX3-1NRIP1RARBRBM39SOX4SREBF1SUPT7LTP53 (p53)
Fatty Acid Metabolism
ACACACAMKK1FASNHMGCRIGF1PRKAB1SREBF1STK11 (LKB1)
Other Prostate Cancer Genes
MKI67TMPRSS2