Target List
Cancer Stem Cell Markers
ABCB5ALCAMALDH1A1 (RALDH1)ATXN1BMI1CD24CD34CD38CD44ENG (EVI-1)ETFAFLOT2GATA3ITGA2ITGA4 (CD49D)ITGA6ITGB1KIT (CD117)MS4A1MUC1 (mucin)PECAM1PROM1PTPRCTHY1
Cell Proliferation
EGFERBB2 (HER-2, NEU)KITLG (SCF)KITLG (SCF)LIN28BNOS2 (iNOS)
Self-Renewal
BMP7DNMT1FGFR2
Pluripotency
KLF4LIN28AMYCNANOGPOU5F1 (OCT4)SOX2
Asymmetric Division
FOXP1HDAC1MYCNSIRT1WNT1
Cell Migration & Metastasis
AXLID1CXCL8 (IL8)KLF17PLAT (TPA)PLAUR (UPAR)SNAI1 (SNAIL)TWIST1TWIST2ZEB1ZEB2
Loss of Stemness
ALDH1A1 (RALDH1)CD34DACH1FOXA2 (HNF3B)PECAM1PTCH1
Signal Transduction
Hippo Signaling
LATS1MERTKSAV1TAZWWC1YAP1
Hedgehog Signaling
PTCH1SMO
Notch Signaling
DLL1 (DELTA1)DLL4JAG1MAML1NOTCH1NOTCH2
WNT Signaling
DKK1EPCAMFZD7WNT1
AKT & PI3 Kinase / mTOR Signaling
ABCG2 (BCRP)GSK3B
STAT / NFκB Signaling
IKBKB (IKKβ)JAK2NFKB1
Cancer Therapeutic Targets
ABCG2 (BCRP)ATMAXLCHEK1DDR1DKK1EPCAMFZD7GSK3BID1IKBKB (IKKβ)JAK2KLF17NFKB1PTCH1SMOSTAT3TGFBR1 (ALK5)WEE1