Target List
Senescence Pathway
AtmBmi1 (Pcgf4)Ccnd1Ccne1Cdk2Cdk4Cdk6Cdkn1a (Cip1, Waf1)Cdkn2a (INK4A, p16, p19ARF)Chek2E2f1E2f3Ets1Ets2Mdm2Nuak1Rb1Rbl2Tp53 (p53)Twist1
Senescence Initiators
p53 / pRb Signaling & the Cell Cycle
Akt1Aldh1a3Ccna2Ccnb1Cdc25cCdkn1c (p57KIP2)Cdkn2b (p15)Cdkn2c (p18)Cited2Creg1Gsk3bId1Igf1rIgfbp3Ing1LOC100909750 (Abl1)Map2k6 (Mek6, Mkk6)Mapk14 (p38alpha)Morc3MycPcnaPik3ca (p110-alpha)Plau (UPAM)Rbl1Serpinb2 (Pai-2)Serpine1 (Pai-1)Sirt1 (QuantiNova Symbol: AABR07044925.1)SparcTgfb1
Interferon Signaling
Aldh1a3Cdkn1a (Cip1, Waf1)Cdkn1b (P27KIP1)Egr1IfngIgfbp3Igfbp7Irf3Irf5Irf7Nfkb1Rb1Serpinb2 (Pai-2)
Insulin Growth Factor (IGF) Related
Igf1Igf1rIgfbp3Igfbp5Igfbp7
MAP Kinase Signaling
HrasMap2k1 (MEK1)Map2k3 (Mek3)Map2k6 (Mek6, Mkk6)Mapk14 (p38alpha)
Oxidative Stress
Aldh1a3HrasMapk14 (p38alpha)Nox4PrkcdSod1Sod2
DNA Damage & Repair
AtmGadd45aNbn (Nbs1)PcnaTerf2TertTp53bp1
Senescence Responses
p53 Effectors
Aldh1a3E2f1HrasIgfbp3Myc
p21 Effectors
Calr
p16 Effectors
Tbx2Tbx3
Cytoskeleton Regulators
Akt1Fn1HrasPik3ca (p110-alpha)Plau (UPAM)Serpine1 (Pai-1)SparcThbs1 (TSP-1, Tsp1)Vim
Cell Adhesion Molecules
Cd44Col1a1Col3a1Tgfb1Tgfb1i1Thbs1 (TSP-1, Tsp1)
Other Senescence Response Genes
Glb1PtenStt3a