Target List
ATM / ATR Signaling
ATMATRATRIPBARD1BRCA1CDC25ACHEK1CHEK2 (RAD53)CSNK2A2FANCD2H2AFXHUS1MDC1PARP1 (ADPRT1)RAD1RAD17RAD50RAD9ARBBP8RNF168RNF8SMC1ATOPBP1TP53 (p53)
DNA Damage & Repair
Nucleotide Excision Repair (NER)
CDK7DDB1DDB2ERCC1ERCC2 (XPD)LIG1NTHL1OGG1PCNAPNKPRPA1SIRT1TP53 (p53)XPAXPC
Base Excision Repair (BER)
APEX1FEN1LIG1MBD4MPGNTHL1OGG1PARP1 (ADPRT1)PCNATP53 (p53)UNGXRCC1
Mismatch Repair (MMR)
ABL1EXO1MLH1MLH3MSH2MSH3PCNAPMS1PMS2TP73
Double-Strand Break (DSB) Repair
ATMBLMBRCA1CHEK1H2AFXHUS1LIG1MDC1MLH1MRE11NBNPRKDCRAD50RAD51RPA1TP53BP1XRCC2XRCC6
Other DNA Repair Genes
ATRATRIPATRXBARD1BRIP1CHEK2 (RAD53)CIB1CRY1FANCAFANCD2FANCGGADD45AGADD45GRAD1RAD17RAD18RAD21RAD51BRAD9ARBBP8REV1RNF168RNF8SMC1ASUMO1TOPBP1XRCC3
Apoptosis
ABL1ATMBARD1BAXBBC3 (PUMA)BRCA1CDKN1A (p21CIP1, WAF1)CHEK2 (RAD53)CIB1CSNK2A2PPP1R15A (GADD34)PRKDCRAD21RAD9ASIRT1TP53 (p53)TP73
Cell Cycle
ATMATRATRIPCDC25ACDC25CCDK7CDKN1A (p21CIP1, WAF1)CHEK1CHEK2 (RAD53)DDIT3 (GADD153, CHOP)MAPK12 (p38GAMMA)MCPH1MDC1PPM1DPPP1R15A (GADD34)TP53 (p53)TP73