Target List
Caspases & Regulators
Caspases
CARD17CARD18CASP1 (ICE)CASP10 (MCH4)CASP14CASP2CASP3CASP4CASP5CASP6CASP7CASP8 (FLICE)CASP9CFLAR (CASPER)CRADDMALT1PYCARD (TMS1, ASC)COP1
Caspase Activation
AIFM3APAF1BAXBBC3 (PUMA)BCL2L10BCL2L13CASP1 (ICE)CASP8AP2CASP9COL4A3CYCSDIABLOEIF2AK3F2 (Thrombin)F2R (PAR1)FOXL2HIP1HSPE1IFNB1IFT57LCKMAP3K5MOAP1MTCH1MYCNLRC4 (IPAF)NLRP1NLRP12NLRP2NLRP3NOD1 (CARD4)PMAIP1 (NOXA)PYCARD (TMS1, ASC)STAT1TNFRSF10A (TRAIL-R)TNFRSF10B (DR5)TNFSF15TP53 (p53)TPD52L1VCP
Caspase Inhibition
BIRC5CD27 (TNFRSF7)DHCR24IFI6LAMTOR5SFN (14-3-3σ, YWHAS)TNFAIP8TNFSF14TRIAP1XIAP
Anti-Apoptotic
Positive Regulation of Anti-Apoptosis
BCL2L1 (BCLXL)BCL2L1 (BCLXL)BCL2L1 (BCLXL)BRECD28ERC1MAPK8IP2 (JIP-1)OPA1PRKAA1 (AMPK)RASA1
Negative Regulation of Anti-Apoptosis
PIK3R2 (p85-BETA)RTN4TNFAIP8
Other Anti-Apoptotic Genes
AATFAKT1ALOX12ANXA1ANXA4API5ATF5AVENAZU1BAG1BAG3BAG4BCL2BCL2A1 (BFL1)BCL2L1 (BCLXL)BCL2L1 (BCLXL)BCL2L1 (BCLXL)BCL2L10BCL2L2BDNFBECN1BFARBIRC2 (c-IAP1)BIRC3 (c-IAP2)BIRC5BIRC6BIRC7BIRC8BNIP1BNIP2BNIP3BRAFCASP2CBX4CCL2 (MCP-1)CD27 (TNFRSF7)CD40LGCEBPBCFDP1CFL1CFLAR (CASPER)CRYAACRYABDAD1DDAH2DHCR24EEF1A2FAIMFAIM2FASFOXO1GDNFGFRALGLO1GSTP1HDAC1HDAC3HIPK3HMGB1HSP90B1HSPA1BHSPA9HSPB1 (HSP27)HTATIP2HTTIER3IFI6IGF1RIL10IL1AIL2IL31RALAMTOR5MALT1MCL1MKL1MPOTESMINMYBL2MYO18ANAIPNFKB1NME5NOL3NOTCH2NPM1NRG2NTF3PAK7PAX7PEA15PIK3CA (p110-alpha)PIM2POGKPOLBPRDX2PRKCZPRLRPROK2PSEN1RELARNF7SEMA4DSERPINB2 (PAI-2)SERPINB9SFRP1SH3GLB1SNCASOCS2SOCS3SONSPHK1SPP1STAMBPTAX1BP1TBX3TGFB1TIAF1TMX1TNFTNFAIP3TNFAIP8TNFRSF10DTNFRSF18TNFRSF6BTNFSF18TPT1TRIAP1TSC22D3VEGFAVHLXIAPYWHAZZC3HC1
Induction of Apoptosis
Induction of Apoptosis by Death Domain Receptors
BIDCRADDDAXXDEDD2FADDIL18TNFTNFRSF10B (DR5)
Induction of Apoptosis by DNA Damage
ABL1AIFM1BCL3BRCA1CHEK2 (RAD53)CIDEACIDEBDYRK2IFI16MBD4MSH6PCBP4PMLSFN (14-3-3σ, YWHAS)TP53 (p53)TP73
Induction of Apoptosis by Oxidative Stress
GPX1PRODHRNF7TP53I3 (PIG3)
Induction of Apoptosis by Extracellular Signals
ADORA1BTKCASP8AP2CD28CD38CD5CFLAR (CASPER)DAPDAP3DAPK1DPF2FASTKMAP3K5NDUFA13PDCD6PRKCARIPK3SPNTIMP3TNFRSF25 (DR3)
Induction of Apoptosis by Intracellular Signals
CDKN1A (p21CIP1, WAF1)CUL1CUL2CUL3CUL4ACUL5HIPK2MYCSART1
Other Pro-Apoptotic Genes
ACVR1BAIFM2AIFM3ALOX15BAPOEBADBAK1BAXBBC3 (PUMA)BCL10BCL2L11BCL2L13BCLAF1BIKBNIP1BNIP3BNIP3LBOKCASP10 (MCH4)CASP3CASP4CASP6CD2CD27 (TNFRSF7)CD70CEBPBCIDECCOL4A3DAPK2DAPK3DCCDDX20DEDDDIABLOEI24ERCC2 (XPD)ERCC3 (XPB)ERN1ERN2FASFASLG (TNFSF6)FEM1BFOXL2FOXO3HRKHTATIP2IFNA2IFNB1IFNGIKBIPIKBKGIL19INHAINHBAJMYLALBALCKLTA (TNFB)MALMAP3K10MAPK1 (ERK2)MX1NDUFS3NGFRNLRP1NLRP3NME3NOTCH2NOX5NUDT2NUPR1PDCD5PLAGL1PLAGL2PLEKHF1PLGPMAIP1 (NOXA)PPP1R13BPPP2CAPPP2R1APPP2R1BPRKCEPRKRAPRUNE2PTENPTHPYCARD (TMS1, ASC)RPS3ARUNX3S100BSAP30BPSERINC3SIPA1SMNDC1SSTSSTR3STK17ASTK17BTBX5TIA1TIAL1TLR2TNFRSF10A (TRAIL-R)TNFRSF19TNFRSF9TNFSF10 (TRAIL)TNFSF14TNFSF8TP53BP2TP63TPD52L1TRADDTRAF3TRAIPUNC13BUTP11LZNF443
TNF Domain Proteins
EDAFASLG (TNFSF6)LTA (TNFB)LTBTNFTNFSF10 (TRAIL)TNFSF14TNFSF15TNFSF8
TNFR Domain Proteins
CD27 (TNFRSF7)CD40 (TNFRSF5)FASLTBRNGFRTNFRSF10A (TRAIL-R)TNFRSF10B (DR5)TNFRSF10DTNFRSF18TNFRSF19TNFRSF1A (TNFR1)TNFRSF1BTNFRSF21TNFRSF25 (DR3)TNFRSF6BTNFRSF8TNFRSF9
BCL2 & BAG Domain Proteins
BAG1BAG3BAG4BAXBCL2BCL2A1 (BFL1)BCL2L1 (BCLXL)BCL2L1 (BCLXL)BCL2L1 (BCLXL)BCL2L10BCL2L13BCL2L2MCL1
BIR Domain Proteins
BIRC2 (c-IAP1)BIRC3 (c-IAP2)BIRC5BIRC6BIRC7BIRC8NAIPXIAP
CARD Domain Proteins
APAF1BCL10BIRC2 (c-IAP1)BIRC3 (c-IAP2)CARD10CARD11CARD14CARD17CARD18CARD6CARD9CASP1 (ICE)CASP2CASP4CASP5CASP9CRADDNLRP1NOD1 (CARD4)NOD2NOL3PYCARD (TMS1, ASC)COP1RIPK2
Death Domain Receptors
CRADDDAPK1EDARFADDMALT1NFKB1NFKB2NGFRPIDD1 (PIDD)RIPK1TNFRSF10A (TRAIL-R)TNFRSF10B (DR5)TNFRSF1A (TNFR1)TNFRSF21TNFRSF25 (DR3)TRADD
TRAF Domain Proteins
TRAF2TRAF3TRAF5TRAF7
Other Apoptosis Regulators
BCL6CEBPGDBPDDIT3 (GADD153, CHOP)GRM4LGALS1MADDMAPK8 (JNK1)NKX3-2POU4F1PROP1RARGSTAT5ASTAT5BTBK1TDGF1TRAF6MAP3K20