Target List
EGFR Signaling
Bcar1CblbEgfEgfrEps8Gab1Grb2HbegfNck2Nup62Rps6ka5Shc1
Platelet-Derived Growth Factor Receptor Signaling
Bcar1PdgfaPdgfbPdgfraPlat (tPA)
Intracellular Signaling
AKT Signaling
Akt1Akt2Akt3BadCasp9Chuk (Ikbka, Ikka)FaslgFoxo3Nfkb1Pten
ERK1 / ERK2 Signaling
EgfrGrb2Kcnh8Map2k1 (MEK1)Mapk1 (Erk2)Mapk3 (ERK1)Mknk1PdgfraRaf1Rps6ka5Shc1SrcStat3
IκB Kinase / NFκB Cascade
Chuk (Ikbka, Ikka)FaslgGsk3aGsk3bNup62RhoaStat1
JAK / STAT Signaling
Eps8Gab1Grb2Jak1Nup62Ppp2caSrcStat1Stat3Stat5a
JNK / p38 Signaling
Map2k4 (Mkk4, Jnkk1)Map3k2 (Mekk2)Mapk10 (Jnk3)Mapk8 (Jnk1)Mapk9 (Jnk2)
MAP Kinase Signaling
Dusp1Dusp6EgfEgfrMap2k1 (MEK1)Map2k7 (Jnkk2)Mapk1 (Erk2)Mapk10 (Jnk3)Mapk3 (ERK1)Mapk8 (Jnk1)Mapk9 (Jnk2)Ppp2caPrkcaShc1
PI3 Kinase Signaling
Pik3ca (p110-alpha)Pik3r1 (PI3KA)Pik3r2Pten
G-Protein Signaling
Grb2HrasNrasNup62Rap1aRasa1Rhoa
Other Intracellular Signaling Molecules
ArafBrafCblbCsnk2a1Csnk2bIkbkb (IKK2)Nck2Pdpk1Plcg1Rps6kb1
Cell Survival & Growth
Apoptosis
Akt1BadBcar1Bcl2BrafCasp3Casp9FaslgFoxo3Il2Lta (Tnfb)Mapk1 (Erk2)Nfkb1Nup62Pik3r2Ppp2caPrkcaPtenRaf1Rasa1Stat1Tp53 (p53)
Cell Cycle
Bcl2Ccnd1Dusp1Dusp6EgfrHrasKrasMapk1 (Erk2)Mapk3 (ERK1)NrasPdgfaPdgfbPpp2caPrkcaPtenRap1aShc1Stat1Tp53 (p53)
Cell Differentiation
Foxo3Il2Ppp2caTp53 (p53)
Cell Growth
Bcar1Ccnd1EgfHbegfIl2PdgfaPdgfbPdgfraPpp2caRasa1Shc1Tp53 (p53)
Cell Motility
Actr2Bcar1EgfrFn1HbegfMap2k1 (MEK1)Mapk8 (Jnk1)PtenStat3
Cell Proliferation
Bcar1Bcl2EgfEgfrEps8Gab1HbegfIl2Nck2Nup62PdgfaPdgfbPdgfraPtenRaf1Shc1Tp53 (p53)
Metabolism
DNA Metabolism
Atf1Atf2 (Creb2)Creb1EgfEgfrFosNup62Ppp2caTp53 (p53)
Lipid Metabolism
ArafBrafPik3r1 (PI3KA)Plcg1Ppp2caPrkcaPtenRaf1Shc1
Protein Metabolism
Actr2Akt1Akt2Akt3ArafAtf1Atf2 (Creb2)BrafCblbChuk (Ikbka, Ikka)Creb1Csnk2a1Dusp1Dusp6EgfrFosGsk3aGsk3bIkbkb (IKK2)Jak1Map2k1 (MEK1)Map2k4 (Mkk4, Jnkk1)Map2k7 (Jnkk2)Map3k2 (Mekk2)Mapk1 (Erk2)Mapk10 (Jnk3)Mapk3 (ERK1)Mapk8 (Jnk1)Mapk9 (Jnk2)Mknk1PdgfraPdpk1Ppp2caPrkcaPtenRaf1Rps6ka5Rps6kb1Src
Other Metabolism Genes
Col1a1Eif4eFn1Mmp7Rasa1
Development
BrafCol1a1HbegfPtenRasa1Stat3
Stimulus Response
Response to Wounding
Bcar1Bcl2Fn1HbegfIl2Nck2Nfkb1PdgfbStat3
Response to Other Stimuli
Akt1Chuk (Ikbka, Ikka)Col1a1Dusp1EgfrFaslgFosKrasLta (Tnfb)Map2k1 (MEK1)Map2k7 (Jnkk2)Mapk1 (Erk2)Mapk8 (Jnk1)Mapk9 (Jnk2)Nfatc3Ppp2caRps6ka5Stat1Stat5aTp53 (p53)
Transcription Factors & Regulators
Akt1Atf1Atf2 (Creb2)CblbCreb1Egr1Eif4eFosFoxo3Ikbkb (IKK2)JunKcnh8Mknk1Nfatc3Nfkb1Nup62Ppp2caRps6ka5Stat1Stat3Stat5aTp53 (p53)
Actin & Calcium Ion Homeostasis
Actr2Bcar1CblbEgfEgfrMmp7Nck2Pdpk1Plcg1PrkcaRasa1RhoaStat1Stat3Stat5a