Target List
Toll-Like Receptors
cd180sigirrtlr1tlr2tlr3tlr4al (TLR4)tlr4ba (TLR4)tlr4bbtlr5atlr5b (TLR5)tlr7tlr8atlr8btlr9
Pathogen-Specific Responses
Bacterial Response
cd180cxcl8afosabhmgb1ahrasbhsp70.3il10il10rail12ail12bail1bil6irak1junltaly86nfkbiaaptgs2arelaripk1l (RIPK1)ripk2tlr2tlr4al (TLR4)tlr4ba (TLR4)tlr4bbtnfbtnfrsf1a
Viral Response
eif2ak2ifng1ifnphi3il12ail12bail6irf3irf7prkrarelatbk1tlr3tlr7tlr8atlr8btnfa
Fungal / Parasitic Response
cxcl8ahrasbhsp70.3tiraptlr2
Toll-Like Receptor (TLR) Signaling
Negative Regulation of Toll-Like Receptor (TLR) Signaling
sarm1sigirrtollip
TICAM1 (TRIF)-Dependent (MYD88-Independent) Signaling
irf3irf7map3k7nr2c2peli1atab1tab2tbk1tlr3tlr4al (TLR4)tlr4ba (TLR4)tlr4bbtraf3traf6
MYD88-Dependent Signaling
irak1map3k7myd88nr2c2tab1tab2tiraptlr1tlr2tlr4al (TLR4)tlr4ba (TLR4)tlr4bbtlr5atlr5b (TLR5)tlr7tlr8atlr8btlr9traf3traf6
Signaling Downstream of Toll-Like Receptors
NFκB Signaling
btkcasp8cd40chukecsitfaddikbkbil10il10rail1birak1irf3irf7map3k1map3k7map4k4nfkb1nfkb2nfkbiaanfkbil1nfrkbpparaarelrelatnfatnfrsf1aube2na
JNK / p38 Signaling
elk1fosabil1bjunmap2k4a (MAP2K4)map2k6map3k1map3k7mapk8a (jnk1)mapk8a (MAPK8)mapk8ip3tnfa
JAK / STAT Signaling
ifng1il12ail12bail6
Interferon Regulatory Factor (IRF) Signaling
ifng1ifnphi1ifnphi3irf1airf3irf7tbk1
Cytokine Signaling
ccl39.6csf3acxcl11.1il1bil6irak1relasigirrtnfatnfrsf1a
Regulation of Adaptive Immunity
cd80/86hspd1ifng1il10il10rail12ail12bail1bmap3k7traf3traf6
Toll-Like Receptor Interacting Proteins & Adaptors
btkhmgb1ahrasbhsp70.3hspd1ly86mapk8ip3myd88peli1aripk1l (RIPK1)ripk2sarm1tiraptollip
Downstream Effectors of Toll-Like Receptor Signaling
casp8ecsiteif2ak2faddirak1irak4map3k7nr2c2pparaaprkratab1tab2traf3traf6ube2na