DNA Damage & Repair
The cellular DNA damage response (DDR) system is a complex network of signaling pathways and repair mechanisms that detects and responds to DNA damage, activating various cellular processes such as DNA repair, cell cycle arrest, checkpoint activation and apoptosis to maintain genomic stability and prevent the propagation of damaged DNA.
ATM Signaling BER pathway DNA damage-induced 14-3-3σ Signaling DNA Double-Strand Break Repair by Homologous Recombination DNA Double-Strand Break Repair by Non-Homologous End Joining Mismatch Repair in Eukaryotes NER Pathway Nucleotide Excision Repair Pathway p53 Signaling Role of BRCA1 in DNA Damage Response UVA-Induced MAPK Signaling UVB-Induced MAPK Signaling UVC-Induced MAPK Signaling